Washington, Sep 21 (IANS) Providing a fresh ray of
hope for diabetic patients, scientists have identified a new gene
associated with fasting glucose and insulin levels in rats, mice and in
humans.
Researchers have identified a gene called Tpcn2, a variant of which was associated with fasting glucose levels in a rat model.
The team has also identified variants within Tpcn2 associated with fasting insulin in humans.
Tpcn2 plays a role in insulin signalling.
"Genome-wide
association studies in humans have identified 60+ genes linked to type 2
diabetes. As we continue to identify genes and variants of interest, we
will evaluate them in multiple models to understand the mechanism of
disease," said Leah Solberg Woods, an associate professor of paediatrics
at the Medical College of Wisconsin.
From their study of Tpcn2
knockout mice (a genetically engineered mouse in which researchers have
inactivated an existing gene), the team demonstrated the difference in
fasting glucose levels and insulin response between the knockout animals
and regular mice.
Glucose tolerance, insulin resistance and beta cell dysfunction are some main causes of type 2 diabetes.
The findings were published in the journal Genetics.